Tesamorelin 10mg
£42.99 per vial · Growth hormone · Research use only
Tesamorelin 10mg research peptide — a synthetic analogue of growth hormone-releasing factor GRF(1-44) (CAS 218949-48-5), supplied lyophilised for in-vitro laboratory research. HPLC purity and LC-MS identity verified per batch, with the COA available on request. UK dispatch.
Tesamorelin in research
Tesamorelin is the longest chain in this catalogue: 44 residues, formula C221H366N72O67S, mass about 5135.8 g/mol, CAS 218949-48-5. It is growth-hormone-releasing factor GRF(1–44) carrying a trans-3-hexenoyl group on the terminal tyrosine, a small acyl modification that obstructs the dipeptidyl-peptidase site the unmodified factor presents. The single sulfur in that formula is the methionine at position 27, and it is the compound's main analytical liability — methionine oxidises to the sulfoxide, adding sixteen mass units, and that adduct is the degradation peak most likely to appear on a trace from an aged or poorly stored lot. A chain of this length is also demanding to assemble and purify, which is why the purity figure on each lot repays close reading.
Specification
| Compound | Tesamorelin |
|---|---|
| CAS number | 218949-48-5 |
| Molecular formula | C221H366N72O67S |
| Molecular weight | 5135.8 g/mol |
| Sequence | GRF(1–44) analogue (44-residue) |
| Vial size | 10mg per vial |
| Physical form | Lyophilised powder |
| Research class | Growth hormone |
| Purity method | RP-HPLC |
| Identity method | LC-MS |
| Documentation | Certificate of analysis available on request |
| Intended use | In-vitro laboratory research only |
Frequently asked questions
What is the hexenoyl group for?
The trans-3-hexenoyl chain is attached to the terminal tyrosine of GRF(1–44). Its role is structural: it obstructs the dipeptidyl-peptidase-4 cleavage that removes the first two residues of the unmodified factor, so the modified chain resists that cleavage where the native sequence does not. It also adds a fixed increment to the expected mass, which is one of the things a mass check confirms.
Which residue is most likely to show degradation?
Methionine 27, the only sulfur-containing residue in the sequence. Oxidation to methionine sulfoxide adds sixteen mass units and shows as a distinct earlier-eluting peak on a reversed-phase trace. A sealed, dry, cold vial is what suppresses it.
Is a 44-residue peptide harder to make than the short sequences here?
Considerably. Every additional coupling step carries a small chance of failure, and the deletion sequences those failures produce become progressively harder to separate from the target as the chain grows. Purity and identity data on long peptides therefore deserve closer reading than on a tripeptide.
Documentation & batch verification
Tesamorelin is analysed per batch: RP-HPLC for purity and LC-MS for identity, with the certificate of analysis available on request. Each released lot number is checkable on our batch verification page, and our documentation standards set out exactly what is reviewed before a product is listed.
Order Tesamorelin 10mg online — UK dispatch · Request an invoice · Verify a batch
Research use only. Not for human or animal consumption.