CJC-1295 (DAC) 2mg
£22.99 per vial · Growth hormone · Research use only
CJC-1295 (DAC) 2mg research peptide — a synthetic growth-hormone-releasing-factor analogue (modified GRF 1-29) carrying a Drug Affinity Complex (DAC) modification for an extended half-life (CAS 863288-34-0), supplied lyophilised for in-vitro laboratory research. HPLC purity and LC-MS identity verified per batch, with the COA available on request. UK dispatch.
CJC-1295 (DAC) in research
The DAC in this compound's name stands for Drug Affinity Complex, and it describes bioconjugation chemistry rather than a formulation. A maleimidopropionyl group is carried on a lysine added at position 30 of a modified GRF(1–29) chain; maleimides react selectively with free thiols, so the construct is built to form a covalent bond with cysteine-34 of serum albumin. Four substitutions in the underlying GRF sequence, at positions 2, 8, 15 and 27, remove the sites that would otherwise limit the chain's stability. CAS 863288-34-0, formula C165H269N47O46, 3647.2 g/mol. At 2mg this is the smallest fill in the catalogue, and the reactive maleimide is the reason the vial is best left sealed until the point of work.
Specification
| Compound | CJC-1295 (DAC) |
|---|---|
| CAS number | 863288-34-0 |
| Molecular formula | C165H269N47O46 |
| Molecular weight | 3647.2 g/mol |
| Sequence | Modified GRF(1–29) + DAC (30-residue) |
| Vial size | 2mg per vial |
| Physical form | Lyophilised powder |
| Research class | Growth hormone |
| Purity method | RP-HPLC |
| Identity method | LC-MS |
| Documentation | Certificate of analysis available on request |
| Intended use | In-vitro laboratory research only |
Frequently asked questions
What does the maleimide group react with?
Free thiols. Maleimides undergo Michael addition with sulfhydryl groups at around neutral pH, which is the basis of the albumin-conjugation design — and also the reason the material should not meet reducing agents or thiol-containing buffer components before it is meant to.
How does the DAC form differ from CJC-1295 without DAC?
The without-DAC form is the modified GRF(1–29) chain on its own: 29 residues, no lysine at position 30 and no maleimidopropionyl group, with a correspondingly lower mass. They are different compounds with different registry numbers, and the blend SKU in this catalogue uses the without-DAC form.
Why is the vial only 2mg?
It is the smallest fill listed. Two milligrams of a 3647 g/mol peptide is a little over half a micromole, which suits characterisation work and short assay series; the fill was set against typical laboratory quantities rather than to match the milligram figures used elsewhere in the range.
Documentation & batch verification
CJC-1295 (DAC) is analysed per batch: RP-HPLC for purity and LC-MS for identity, with the certificate of analysis available on request. Each released lot number is checkable on our batch verification page, and our documentation standards set out exactly what is reviewed before a product is listed.
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Research use only. Not for human or animal consumption.