MOTS-c 10mg
£25.99 per vial · Metabolic & longevity · Research use only
MOTS-c 10mg research peptide — a synthetic 16-residue mitochondrial-derived peptide (CAS 1627580-64-6), supplied lyophilised for in-vitro laboratory research. HPLC purity and LC-MS identity verified per batch, with the COA available on request. UK dispatch.
MOTS-c in research
MOTS-c is the only sequence in this catalogue that is not encoded in the nuclear genome. Its sixteen residues, MRWQEMGYIFYPRKLR, are read from an open reading frame inside the mitochondrial 12S ribosomal RNA gene, so the mitochondrial genetic code rather than the standard one governs its translation — the defining feature of the small group of peptides described as mitochondrially derived. Chemically it is a cationic chain: three arginines and a lysine against a single glutamate. Two methionines make it oxidation-sensitive, and a hydrophobic run through the middle of the sequence can drive aggregation in poorly matched solvent conditions. CAS 1627580-64-6, formula C101H152N28O22S2, 2174.6 g/mol, supplied as a 10mg lyophilised fill.
Specification
| Compound | MOTS-c |
|---|---|
| CAS number | 1627580-64-6 |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2174.6 g/mol |
| Sequence | MRWQEMGYIFYPRKLR |
| Vial size | 10mg per vial |
| Physical form | Lyophilised powder |
| Research class | Metabolic & longevity |
| Purity method | RP-HPLC |
| Identity method | LC-MS |
| Documentation | Certificate of analysis available on request |
| Intended use | In-vitro laboratory research only |
Frequently asked questions
What does "mitochondrially derived" mean for this sequence?
The open reading frame sits within the mitochondrial 12S rRNA gene rather than in nuclear DNA, and peptides in this small group are read using the mitochondrial genetic code, which differs from the standard code at several codons. It is an unusual origin among research peptides — the material supplied here is nonetheless made by ordinary solid-phase chemistry.
Is the peptide prone to aggregation?
The middle of the sequence, Gly-Tyr-Ile-Phe-Tyr, is hydrophobic enough that poorly matched solvent conditions can give cloudy or incompletely dissolved preparations. Solvent selection belongs to the experimental design; support cannot specify conditions for a given assay.
How strongly charged is the peptide at neutral pH?
Three arginines and a lysine against one glutamate leave it strongly cationic at neutral pH. That governs its behaviour on ion-exchange columns and its tendency to adsorb to anionic surfaces such as untreated plasticware, which is why low-binding vessels are a usual precaution for cationic peptides at low concentration.
Documentation & batch verification
MOTS-c is analysed per batch: RP-HPLC for purity and LC-MS for identity, with the certificate of analysis available on request. Each released lot number is checkable on our batch verification page, and our documentation standards set out exactly what is reviewed before a product is listed.
Order MOTS-c 10mg online — UK dispatch · Request an invoice · Verify a batch
Research use only. Not for human or animal consumption.