MOTS-c — Compound Overview
A researcher-focused overview of MOTS-c: what the compound is, its chemistry, how it appears in the published literature, and how Index Peptides documents each batch.
Last updated: 2026-08-21 · By: Index Peptides technical team
Key facts
| Compound | MOTS-c |
|---|---|
| CAS number | 1627580-64-6 |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2174.6 g/mol |
| Sequence | MRWQEMGYIFYPRKLR |
| Supplied formats | 10mg per vial |
| Intended use | In-vitro laboratory research only |
What is MOTS-c?
MOTS-c is a synthetic 16-amino-acid peptide whose sequence corresponds to a mitochondrial-derived peptide encoded in the mitochondrial genome. The material is produced by solid-phase peptide synthesis and supplied as a lyophilised powder.
MOTS-c is classified as a research chemical. It is not an approved medicine, and Index Peptides supplies it strictly for in-vitro laboratory research.
MOTS-c in the research literature
MOTS-c appears in the published literature as a mitochondrial-derived peptide, studied in metabolic research contexts. The body of work is predominantly preclinical; controlled human data are lacking, and no conclusions about effects in humans can be drawn from it.
Form, handling and storage
MOTS-c is supplied as a lyophilised (freeze-dried) powder in a sealed vial. Lyophilised peptides are best stored at -20°C, desiccated and protected from light; long-term stability data are batch-specific and recorded against the batch record.
Batch documentation at Index Peptides
Every released batch of MOTS-c is HPLC purity tested and LC-MS identity confirmed, with the certificate of analysis published on the product page and verifiable by lot number through the batch lookup tool.
Frequently asked questions
Is MOTS-c approved for human use?
No. MOTS-c is not an approved medicine anywhere in the world. Index Peptides supplies it strictly for in-vitro laboratory research — not for human or animal consumption, administration or any in-vivo use.
What is the CAS number for MOTS-c?
1627580-64-6, with a molecular weight of approximately 2174.6 g/mol.
How is each batch verified?
By reversed-phase HPLC for purity and LC-MS for identity (expected vs detected mass). The certificate of analysis is published on the product page, and any batch can be checked by lot number on the verify page.
How do I reconstitute MOTS-c?
Reconstitution is a laboratory handling procedure, not a use instruction. Our documentation-led reconstitution guide covers the mechanics of dissolving lyophilised peptide powders: https://indexpeptides.uk/guides/peptide-reconstitution-guide. Handling is the responsibility of the qualified researcher.
What is the shelf life of MOTS-c?
As supplied (lyophilised powder in a sealed vial), MOTS-c is stored at -20C, desiccated and protected from light. Long-term stability is documented per batch on the certificate of analysis; treat the batch record as the authoritative shelf-life reference for that lot.
What is the difference between the sizes?
The difference is the nominal peptide content per vial. MOTS-c is supplied as 10mg vials. Every format carries the same batch documentation and purity testing.
What does the certificate of analysis show?
Every released batch of MOTS-c is documented with its certificate of analysis: the purity results, identity confirmation and the lot number, published on the product page and checkable through the batch lookup tool. The COA is the authoritative record for that batch.
References
Research use only. Not for human or animal consumption.