Semaglutide 5mg
£39.99 per vial · Weight management · Research use only
Semaglutide 5mg research peptide — a synthetic 31-residue GLP-1 receptor analogue peptide (CAS 910463-68-2), supplied lyophilised for in-vitro laboratory research. HPLC purity and LC-MS identity verified per batch, with the COA available on request. UK dispatch.
Semaglutide in research
Semaglutide is a 31-residue analogue of glucagon-like peptide-1, differing from the native GLP-1(7-37) sequence at three defined points. Alanine at position eight is replaced by alpha-aminoisobutyric acid, obstructing a dipeptidyl-peptidase-4 cleavage site; lysine at position 34 is replaced by arginine, leaving only one lysine available for modification; and that remaining lysine at position 26 carries a C18 diacid attached through a glutamate-and-ethylene-glycol spacer. CAS 910463-68-2, formula C187H291N45O59, mass 4113.6 g/mol. The 5mg fill is the smallest of the incretin-receptor peptides listed here. Index Peptides keeps this listing under invoice-only review, documents each lot before release, and supplies it for in-vitro research and no other purpose.
Specification
| Compound | Semaglutide |
|---|---|
| CAS number | 910463-68-2 |
| Molecular formula | C187H291N45O59 |
| Molecular weight | 4113.6 g/mol |
| Sequence | 31-residue GLP-1 analogue |
| Vial size | 5mg per vial |
| Physical form | Lyophilised powder |
| Research class | Weight management |
| Purity method | RP-HPLC |
| Identity method | LC-MS |
| Documentation | Certificate of analysis available on request |
| Intended use | In-vitro laboratory research only |
Frequently asked questions
How does the sequence differ from native GLP-1?
Three changes to GLP-1(7-37): alpha-aminoisobutyric acid for alanine at position eight, arginine for lysine at position 34, and acylation of the remaining lysine at position 26 with a C18 diacid on a short spacer. The first obstructs a protease site; the second leaves a single site for the third.
Why is lysine 34 replaced with arginine?
To control where the acyl chain goes. Both residues are basic, but only lysine offers the primary amine the acylation chemistry targets, so removing one of the two lysines lets the modification be directed to a single defined position rather than producing a mixture of isomers.
What should mass confirmation show for this compound?
A detected mass matching the 4113.6 g/mol calculated for the fully modified chain. A peak short by the mass of the acyl group would indicate unmodified peptide, and deletion sequences sit lower still. That is the value of reading mass confirmation alongside a purity trace rather than relying on either on its own.
Documentation & batch verification
Semaglutide is analysed per batch: RP-HPLC for purity and LC-MS for identity, with the certificate of analysis available on request. Each released lot number is checkable on our batch verification page, and our documentation standards set out exactly what is reviewed before a product is listed.
Request an invoice · Verify a batch
Research use only. Not for human or animal consumption.